Lessons from Studies of Tumour Heterogeneity


Booking is now open for our second virtual Research Talk, to be delivered by Professor Greg Hannon (e2016).

Professor Hannon has made fundamental contributions to our understanding of small RNA biology.  His discoveries include Dicer, the content and mechanism of action of RISC, and the first small RNA oncogene. His lab identified endo-siRNAs in mammalian germ cells and the role of pseudogenes in their production.  His work uncovered a conserved, small RNA-based innate immune system (the piRNA pathway) that essentially distinguishes genes (self) from transposons (non-self) and selectively silences the latter, and has deciphered the biochemical mechanisms by which this pathway acts.  piRNAs are essential for the perpetuation of all animal species, since failure to guard germ genomes almost universally leads to sterility. Finally, Professor Hannon has developed a number of widely-used approaches.  These include short-hairpin RNAs, oligonucleotide libraries made by in-situ synthesis, a foundation of modern systems and synthetic biology, and exome capture, which is now in use in the clinic.  

Professor Hannon is Director and Senior Group Leader at the Cancer Research UK Cambridge Institute, and has been a Fellow at Trinity College since 2016.

This event will be recorded.