De Officiis by Marcus Tullius Cicero
Mainz: Johann Fust & Peter Schoeffer, 1466
This is the oldest dated printed book in the Wren Library.
The layout of the page in the first printed books was virtually identical to that of manuscripts. The text is heavily abbreviated, as many manuscript books were, with a dash above certain letters to denote a contraction. The wide margins allow for copious notes.